Ethyl Acetate → HCID 71245549, compound

Participants

Reaction Conditions

Reaction Steps

2.82 g (12.3 mmol) of 6-methoxy-4-oxochroman-3-aminium chloride were dissolved in tetrahydrofuran under nitrogen atmosphere and cooled to 0° C. with an ice bath. Diisopropylethylamine and ethyl carbononochloridate were added. The mixture was allowed to warm to room temperature and stirred for 30 min. The mixture was diluted with ethyl acetate and washed with saturated ammonium chloride solution (2×) and water (1×). The organic phase was washed dried over MgSO4, and concentrated in vacuo to give 3.5 g (13.2 mmol, quant.) of crude material.

Provenance & Evidence