Boron tribromide → HCID 71245529, compound

Participants

Reaction Conditions

Reaction Steps

3.19 g (9.3 mmol) of ethyl 4-benzyl-6-methoxychroman-3-ylcarbamate under nitrogen atmosphere were dissolved in 90 ml of methylene dichloride. At 0° C. 28.0 ml (28.0 mmol, 1 M in methylene dichloride) of boron tribromide were added. The reaction mixture was stirred at 0° C. for 2 hours. At 0° C. saturated sodium hydrogencarbonate solution was added to the reaction mixture. The phases were separated and the aqueous phase was extracted with methylene dichloride. The combined organic layers were washed with brine, dried over MgSO4 and the solvent was evaporated to yield 3.0 g (9.2 mmol, 99) of the crude product.

Provenance & Evidence