反应详情

温度

75 °C

A mixture of (3,4,5-trifluorophenyl)boronic acid (0.5 g, 2.84 mmol), 2-bromo-3,3,3-trifluoroprop-1-ene (596 mg., 3.41 mmol, 1.2 eq), Na2CO3 (0.90 g, 8.52 mmol, 3 eq) and Pd(dppf)Cl2 (232 mg, 10% mol) in DME (20 mL) and water (2 mL) was heated at 70 to 80° C. for 2 h. The mixture was cooled to 0° C. with ice-water bath, and then used to next step without further purification.

1. temperatureThe mixture was cooled to 0° C. with ice-water bath
2. customused to next step without further purification