HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 4-(4-Fluoro-2-methoxy-phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate | HCID 2759834 | — |
| Edukt | 4-Fluoro-2-methoxyaniline | HCID 13532228 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 4-(4-Fluoro-2-methoxy-phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester | HCID 58413295 | — |
Reaktionsschritte
4-Chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (15.0 g), 4-fluoro-2-methoxyaniline (9.5 g), 4M hydrochloric acid in dioxane (4.5 ml) and dioxane (100.0 ml) were stirred at 100° C. overnight. Then the mixture was filtrated and the solid was dried in vacuo.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08853193B2 |
| Quelldatensatz | uspto-grants-2014_10 |
| ORD ID | ord-7c8f94e145f6405a85e6717d075199d6 |
| Quellennotiz | uspto-grants-2014_10 |