Tert-butyl (2-hydroxybutyl)carbamate → Methyl 4-(2-(1-(tert-butoxycarbonylamino)butan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

HRID 532279Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 532279
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([O:21][CH3:22])=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([OH:23])[CH:3]=1.O[CH:25]([CH2:35][CH3:36])[CH2:26][NH:27][C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31]>>[C:30]([O:29][C:28]([NH:27][CH2:26][CH:25]([O:23][C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[CH:6][C:5]=1[NH:8][C:9]1[C:10]2[C:17]([CH3:18])=[C:16]([C:19]([O:21][CH3:22])=[O:20])[S:15][C:11]=2[N:12]=[CH:13][N:14]=1)[CH2:35][CH3:36])=[O:34])([CH3:33])([CH3:32])[CH3:31]

Komponenten

3

Edukt 2

HCID 10198004Tert-butyl (2-hydroxybutyl)carbamateHCID 58413076Methyl 4-(4-fluoro-2-hydroxyphenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate

Produkt 1

HCID 58413368Methyl 4-(2-(1-(tert-butoxycarbonylamino)butan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

Versuchsvorschrift

Synthesized analogously to example 9.1 using methyl 4-(4-fluoro-2-hydroxyphenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate and tert-butyl 2-hydroxybutylcarbamate.

Quellen und Nachweise

ORD-Eintrag
ord-6fdfa88c6d324260979f6c83bd3f4481
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08853193B2

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