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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 532285Generated: October 30, 2026

Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate → Methyl 5-methyl-4-(2-(1,1,1-trifluoropropan-2-yloxy)pyridin-3-ylamino)thieno[2,3-d]pyrimidine-6-carboxylate

https://huagongshe.com/reaction/532285

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateHCID 2759834—
ReactantHCID 58413331HCID 58413331—
ProductMethyl 5-methyl-4-(2-(1,1,1-trifluoropropan-2-yloxy)pyridin-3-ylamino)thieno[2,3-d]pyrimidine-6-carboxylateHCID 58413383—

Reaction Conditions

Temperature110 °C

Reaction Steps

Prepared analogously to example 1.1 by heating under microwave irradiation at 110° C. using 2-(1,1,1-trifluoropropan-2-yloxy)pyridin-3-amine and 4-Chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08853193B2
Source datasetuspto-grants-2014_10
ORD IDord-1716bfd95b2c4d68bd0c4f74afedf5c1
Source noteuspto-grants-2014_10