HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 53374891, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 53374892 | HCID 53374892 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 53374891 | HCID 53374891 | — |
Reaction Steps
5-Methyl-4-(2-(1,1,1-trifluoropropan-2yloxy)pyridin-3-ylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid (278 mg), HATU (320 mg) and Hünig's Base (144 μl) were dissolved in DMF (6.5 ml) at 0° C. The reaction was stirred for 30 minutes after this time NH3 in dioxane (0.5 M; 5.3 ml) was added. The reaction was allowed to warm to room temperature overnight. The reaction mixture was concentrated in vacuo. The residue was extracted with dichloromethane and water. The organic layer was separated, dried and evaporated. The crude product was purified by chromatography (silica/dichloromethane: methanol: NH3 90:10:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853193B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-9587113636e04ce8bd93d7c6216aab2c |
| Source note | uspto-grants-2014_10 |