Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate → HCID 58413356, compound

HRID 532287Notes

Reaction equation

HRID 532287 reaction equation
[F:1][CH2:2][CH:3]([O:6][C:7]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:8]=1[NH2:9])[CH2:4][F:5].[CH3:15][O:16][C:17]([C:19]1[S:28][C:22]2[N:23]=[CH:24][N:25]=[C:26](Cl)[C:21]=2[C:20]=1[CH3:29])=[O:18]>>[F:5][CH2:4][CH:3]([O:6][C:7]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:8]=1[NH:9][C:26]1[C:21]2[C:20]([CH3:29])=[C:19]([C:17]([O:16][CH3:15])=[O:18])[S:28][C:22]=2[N:23]=[CH:24][N:25]=1)[CH2:2][F:1]

Participants

3

Reactant 2

HCID 2759834Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateHCID 58413286HCID 58413286, compound

Product 1

HCID 58413356HCID 58413356, compound

Procedure

Prepared analogously to example 21.1 using 2-(1,3-difluoropropan-2-yloxy)-4-fluoroaniline and 4-Chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester.

Sources & evidence

ORD record
ord-e815c3a092c445138dcd3a59a158f683
Source dataset
uspto-grants-2014_10
Patent number
US08853193B2

Reaction notes

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