HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 532304Generated: October 31, 2026
Diisopropylethylamine → HCID 58413247, compound
https://huagongshe.com/reaction/532304
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | Ammonia methanol | HCID 21705897 | — |
| Reactant | HCID 46182084 | HCID 46182084 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 58413247 | HCID 58413247 | — |
Reaction Steps
HATU (182.0 mg) was added to an ice cooled solution of 150 mg 4-(2-Isopropoxypyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and DIPEA (83.0 μl) in DMF (3.0 ml). The mixture was stirred at 0° C. for 20 min then ammonia/MeOH (7M; 1.5 ml) was added and it was allowed to warm to room temperature overnight. The mixture was diluted with EtOAc and washed with water, 2M NaOH and concentrated in vacuo. The residue was triturated with Et2O and filtered to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08853193B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-671b82b60ff343478a1df6fcbb4a7e4d |
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| Source note | uspto-grants-2014_10 |
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