Isopropanol → Methyl 4-[4-cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

Participants

Reaction Steps

4-Chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (0.2 g), 4-amino-3-(2-fluoro-1-fluoromethyl-ethoxy)-benzonitrile (0.17 g), p-toluenesulfonic acid monohydrate (0.16 g) and isopropanol (3.0 ml) were stirred at 90° C. for 2 hours. Then the mixture was poured in water and filtrated. The solid was washed with water and dried in an oven at 70° C.

Provenance & Evidence