HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethyl-1,3-propanediamine → HCID 58413287, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethyl-1,3-propanediamine | HCID 7993 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58413357 | HCID 58413357 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58413287 | HCID 58413287 | — |
Reaction Steps
4-[4-Cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (100 mg), HATU (114 mg) and TEA (52 μl) were dissolved in DMF (4 ml). N,N-dimethyl-1,3-propanediamine (31 μl) was added. The mixture was stirred for 1 hour at rt. Then the mixture was poured in water and filtrated. The solid was washed with water and dried in an oven at 70° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853193B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-161826df9043429296179d35b94b72fb |
| Source note | uspto-grants-2014_10 |