HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 532311Generated: November 4, 2026
Cesium carbonate → HCID 58413232, compound
https://huagongshe.com/reaction/532311
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | tert-Butyl 2-bromopropanoate | HCID 545327 | — |
| Reactant | Methyl 4-(4-fluoro-2-hydroxyphenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate | HCID 58413076 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 58413232 | HCID 58413232 | — |
Reaction Steps
2-Bromopropionic acid tert-butyl-ester (1.4 g) was added to methyl 4-(4-fluoro-2-hydroxyphenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (Intermediate III) (2.00 g) and cesium carbonate (4.8 g) in ACN (50 ml) and stirred at 60° C. for 2 hours. The mixture was diluted with water, filtrated and washed with water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08853193B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-d7e315cc129044658d0db68a660d6e75 |
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| Source note | uspto-grants-2014_10 |
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