反应详情

(6-Chloro-4-methylpyridazin-3-yl)hydrazine (W3.002; 4.6 g) were initially charged in EtOH (330 ml) and water (70 ml) while stirring at RT. Thereafter, cyanogen bromide in a mixture of EtOH (170 ml) and water (30 ml) was slowly added dropwise at RT. After stirring at RT for 6 h, the mixture was left to stand overnight. Then the mixture was dried and the residue was purified using silica gel (40 g cartridge, DCM/methanol gradient of 0-10% in 30 min). 7.3 g of the title compound were obtained.

1. additionwas slowly added dropwise at RT
2. waitthe mixture was left
3. waitto stand overnight
4. customThen the mixture was dried
5. customthe residue was purified
6. customsilica gel (40 g cartridge, DCM/methanol gradient of 0-10% in 30 min)