Cyanogen Bromide → HCID 58136895, compound

HRID 532346Notes

Reaction equation

HRID 532346 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[N:14]=[N:13][C:12]([NH:15][NH2:16])=[CH:11][C:10]=1[CH:17]1[CH2:19][CH2:18]1.[N:20]#[C:21]Br>>[Cl:8][C:9]1[C:10]([CH:17]2[CH2:19][CH2:18]2)=[CH:11][C:12]2[N:13]([C:21]([NH2:20])=[N:16][N:15]=2)[N:14]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 86650807HCID 86650807, compound

Product 1

HCID 58136895HCID 58136895, compound

Procedure

(6-Chloro-5-cyclopropylpyridazin-3-yl)hydrazine trifluoroacetic acid salt (W3.012; 400 mg) was converted and worked up analogously to W2.008, except that, instead of 0.5, one further equivalent of cyanogen bromide solution was added. 260 mg of the title compound were obtained in sufficient purity.

Sources & evidence

ORD record
ord-42a76d4d08a64ae9a7b3caf2cc4bed68
Source dataset
uspto-grants-2014_10
Patent number
US08853206B2

Reaction notes

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