Methyl isothiocyanate → N'-(6-Chloro-4,5-dimethylpyridazin-3-yl)amino-N-methylthiourea

HRID 532352Notes

Reaction equation

HRID 532352 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][NH2:9])=[C:4]([CH3:10])[C:3]=1[CH3:11].[CH3:12][N:13]=[C:14]=[S:15]>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][NH:9][C:14](=[S:15])[NH:13][CH3:12])=[C:4]([CH3:10])[C:3]=1[CH3:11]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 126480423-Chloro-6-hydrazinyl-4,5-dimethylpyridazine

Product 1

HCID 58136868N'-(6-Chloro-4,5-dimethylpyridazin-3-yl)amino-N-methylthioureaYield 98.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(6-Chloro-4,5-dimethylpyridazin-3-yl)hydrazine (W3.006; 8.00 g) was dissolved in DCM (400 ml) and admixed with methyl isothiocyanate (3.39 g). Subsequently, the mixture was stirred at RT for 24 h and left to stand over the weekend. The precipitate was filtered off, washed with DCM and dried in a drying cabinet at 45° C. 11.25 g of the title compound were obtained.

Workup

  1. waitleft
  2. filtrationThe precipitate was filtered off
  3. washwashed with DCM
  4. customdried in a drying cabinet at 45° C

Sources & evidence

ORD record
ord-3065732a54a846f6b1b830b2af534ceb
Source dataset
uspto-grants-2014_10
Patent number
US08853206B2

Reaction notes

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