Benzamide → 1-(5-bromo-2,3-dimethoxyphenyl)ethanone

HRID 532378Notes

Reaction equation

HRID 532378 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([O:13][CH3:14])[C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[C:15](N)(=O)C1C=CC=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]([O:13][CH3:14])[C:5]([O:11][CH3:12])=[C:6]([C:7](=[O:9])[CH3:15])[CH:10]=1

Participants

3

Reactant 2

HCID 2331BenzamideHCID 3228725-bromo-2,3-dimethoxybenzoic acid

Product 1

HCID 3444841-(5-bromo-2,3-dimethoxyphenyl)ethanone

Procedure

5-Bromo-2,3-dimethoxybenzoic acid (2 g) was converted to the benzamide derivative analogously to O3.043, and the latter to the title compound analogously to O2.059. 1.1 g of the title compound were obtained. LC-MS rt: 3.70 min [M+H]+: 259.0 (met. d)

Sources & evidence

ORD record
ord-f7ab261b93344f2daca57ab9b0f893df
Source dataset
uspto-grants-2014_10
Patent number
US08853206B2

Reaction notes

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