Methyl iodide → Methyl 3-bromo-5-methoxybenzoate

HRID 532402Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([OH:12])[CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[CH3:13]I>>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([O:12][CH3:13])[CH:11]=1)[C:5]([O:7][CH3:8])=[O:6]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 53216607Methyl 3-bromo-5-hydroxybenzoate

Product 1

HCID 15618226Methyl 3-bromo-5-methoxybenzoate

Procedure

Methyl 3-bromo-5-hydroxybenzoate (O6.032; 2.52 g) was alkylated with methyl iodide and worked up analogously to the conditions of O5.043. 2.5 g of the title compound were obtained.

Sources & evidence

ORD record: ord-a576028e122549b2a189ea03cbfe5935
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08853206B2

Reaction notes

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