反应详情

Subsequently, the 3-pentafluorosulfanyl-5-nitrobenzoic acid (5 g) was dissolved in methanol (300 ml), Raney nickel (about 750 mg) was added and hydrogenation was effected under a hydrogen atmosphere (hydrogen balloon). After 3 h, the catalyst was filtered off and the filter residue was washed thoroughly with methanol. The filtrate was concentrated and dried. The residue was purified using silica gel (2×50 g cartridge, n-heptane/EA gradient of 0-100% within 60 min). 3.9 g of the title compound were obtained.

1. filtrationthe catalyst was filtered off
2. washthe filter residue was washed thoroughly with methanol
3. concentrationThe filtrate was concentrated
4. customdried
5. customThe residue was purified
6. customsilica gel (2×50 g cartridge, n-heptane/EA gradient of 0-100% within 60 min)