反应详情

3-tert-Butyl-5-hydroxybenzoic acid (O7.043; 1.93 g) was dissolved in methanol (20 ml), and thionyl chloride (0.937 ml) was slowly added dropwise while stirring. After stirring at 65° C. for 1 h, the mixture was dried, the residue was taken up in DCM, and the solution was washed with saturated sodium hydrogencarbonate solution, dried over MgSO4, filtered and concentrated by rotary evaporation. 2.19 g of the title compound were obtained.

1. stirringAfter stirring at 65° C. for 1 h
2. customthe mixture was dried
3. washthe solution was washed with saturated sodium hydrogencarbonate solution
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated by rotary evaporation