p-Fluoronitrobenzene → 3-(4-Nitrophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

HRID 532439Notes

Reaction equation

HRID 532439 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][CH:11]([OH:16])[CH2:12]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].F[C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=1>>[C:1]([O:5][C:6]([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][CH:11]([O:16][C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=1)[CH2:12]2)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 21187725tert-Butyl 3-hydroxy-8-azabicyclo(3.2.1)octane-8-carboxylate

Product 1

HCID 689397953-(4-Nitrophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Procedure

3-Hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester was reacted with 1-fluoro-4-nitrobenzene by method D. The product with the molecular weight of 348.40 (C18H24N2O5) was obtained in this way; MS (ESI): 349 (M+H+)

Workup

  1. customThe product with the molecular weight of 348.40 (C18H24N2O5) was obtained in this way

Sources & evidence

ORD record
ord-b8872718958b4ab5948eae323c6f1e77
Source dataset
uspto-grants-2014_10
Patent number
US08853208B2

Reaction notes

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