HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethynylcyclopentanol → 3-[3-Fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(1-hydroxycyclopentylethynyl)-3H-thieno[3,2-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethynylcyclopentanol | HCID 87074 | — |
| Reactant | 6-Bromo-3-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one | HCID 68936503 | — |
| Product | 3-[3-Fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(1-hydroxycyclopentylethynyl)-3H-thieno[3,2-d]pyrimidin-4-one | HCID 24969506 | — |
Reaction Steps
6-Bromo-3-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one was reacted with 1-ethynylcyclopentanol by method R.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853208B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-a8e98c0cbb0648a2b6d0d7c9bfc3abee |
| Source note | uspto-grants-2014_10 |