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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 532441Generated: October 30, 2026

3-Fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)aniline → 6-Bromo-3-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

https://huagongshe.com/reaction/532441

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)anilineHCID 19627246—
Reactant5-Bromo-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl esterHCID 60027040—
SolventIsopropanolHCID 3776—
Product6-Bromo-3-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-oneHCID 68936503—

Reaction Steps

5-Bromo-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester was reacted with 3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenylamine by method A with addition of isopropanol in addition. The product with the molecular weight of 438.32 (C18H17BrFN3O2S) was obtained in this way; MS (ESI): 438, 440 (M+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08853208B2
Source datasetuspto-grants-2014_10
ORD IDord-a2ce043b1d0240078a91013974122a90
Source noteuspto-grants-2014_10