反应详情

1N sodium hydroxide solution (4 mL) was added to a solution of 5-bromo-3-nitrothiophene-2-carboxylic acid methyl ester (975 mg) in 1:1 THF/methanol (4 mL) and the solution was stirred at room temperature for 1 h. The solution was partitioned between water and ethyl acetate. The aqueous phase was brought to pH 1 with 2N HCl, extracted with ethyl acetate, dried over magnesium sulfate and concentrated. The product with the molecular weight of 252.04 (C5H2BrNO4S) was obtained in this way; MS (ESI): 252 and 254 (M+H+).

1. customThe solution was partitioned between water and ethyl acetate
2. extractionextracted with ethyl acetate
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. customThe product with the molecular weight of 252.04 (C5H2BrNO4S) was obtained in this way