Bromine → 7-Bromothieno(3,2-d)pyrimidin-4-ol
Reaction equation
[N:1]1[C:6]2[CH:7]=[CH:8][S:9][C:5]=2[C:4](=[O:10])[NH:3][CH:2]=1.[Br:11]Br>C(O)(=O)C>[Br:11][C:7]1[C:6]2[N:1]=[CH:2][NH:3][C:4](=[O:10])[C:5]=2[S:9][CH:8]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 120 °C
Procedure
Thieno[3,2-d]pyrimidin-4(3H)-one (12.5 g) was dissolved in acetic acid (52 mL), and bromine (13 mL) was added thereto. The reaction mixture was stirred at 120° C. for 12 hours in a hermetically sealed reactor. The reaction mixture was cooled to room temperature and distilled under reduced pressure to remove acetic acid. The reaction mixture was placed in ice water, and the solid thus obtained was filtered and washed with ether, and dried to obtain the title compound (7.8 g).
Workup
- temperatureThe reaction mixture was cooled to room temperature
- distillationdistilled under reduced pressure
- customto remove acetic acid
- customthe solid thus obtained
- filtrationwas filtered
- washwashed with ether
- customdried
Sources & evidence
- ORD record
- ord-8486b65b493f45e6914e672b9f49f043
- Source dataset
- uspto-grants-2014_10
- Patent number
- US08853213B2
Reaction notes
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