2-Chloro-5-ethylpyrimidine → HCID 57414343, compound

HRID 532473Notes

Reaction equation

HRID 532473 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:15]3[N:16]=[CH:17][N:18]=[C:19]([N:20]4[CH2:25][CH2:24][N:23]([C:26](OC(C)(C)C)=O)[CH2:22][CH2:21]4)[C:14]=3[S:13][CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].ClC1[N:39]=[CH:38][C:37]([CH2:40][CH3:41])=[CH:36][N:35]=1>>[CH2:40]([C:37]1[CH:36]=[N:35][C:26]([N:23]2[CH2:24][CH2:25][N:20]([C:19]3[C:14]4[S:13][CH:12]=[C:11]([C:8]5[CH:7]=[CH:6][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:10][CH:9]=5)[C:15]=4[N:16]=[CH:17][N:18]=3)[CH2:21][CH2:22]2)=[N:39][CH:38]=1)[CH3:41]

Participants

3

Reactant 2

HCID 35727632-Chloro-5-ethylpyrimidineHCID 57414342HCID 57414342, compound

Product 1

HCID 57414343HCID 57414343, compound

Procedure

The compound obtained in Example 10 was deprotected as in Step 5-3), and subjected to a reaction with 2-chloro-5-ethylpyrimidine under conditions similar to Example 1 to obtain the title compound.

Sources & evidence

ORD record
ord-7a1de0cab68e4f2ab97118fe56041abe
Source dataset
uspto-grants-2014_10
Patent number
US08853213B2

Reaction notes

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