Water → HCID 68299382, compound

Participants

Reaction Steps

4-iodo-benzenesulfinic acid (250 mg, 0.933 mmol) obtained in Step 20-1 was dissolved in dimethylformamide (3 mL), and triethylamine (0.2 mL, 1.21 mmol) and 1-iodopropane (0.3 mL, 2.33 mmol) was sequentially added thereto, followed by stirring at room temperature for 2 hours. After completion of the reaction, the reaction mixture was mixed with water and extracted three times with ethyl acetate, and the organic layer thus obtained was sequentially washed with water and a saline solution. The washed organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure, followed by purification using column chromatography (Hex:EA=5:1) to obtain the title compound (200 mg).

Provenance & Evidence