4-(Methanesulfonyl)phenylboronic acid → HCID 57414987, compound

HRID 532485Notes

Reaction equation

HRID 532485 reaction equation
Br[C:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10]([O:11][CH:12]3[CH2:17][CH2:16][N:15]([C:18]4[O:22][N:21]=[C:20]([CH:23]([CH3:25])[CH3:24])[N:19]=4)[CH2:14][CH2:13]3)[C:5]=2[N:4]([CH3:26])[CH:3]=1.[N+:27]([C:30]1[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=1)([O-:29])=[O:28].CS(C1C=CC(B(O)O)=CC=1)(=O)=O>>[CH:23]([C:20]1[N:19]=[C:18]([N:15]2[CH2:16][CH2:17][CH:12]([O:11][C:10]3[C:5]4[N:4]([CH3:26])[CH:3]=[C:2]([C:33]5[CH:34]=[CH:35][C:30]([N+:27]([O-:29])=[O:28])=[CH:31][CH:32]=5)[C:6]=4[N:7]=[CH:8][N:9]=3)[CH2:13][CH2:14]2)[O:22][N:21]=1)([CH3:25])[CH3:24]

Participants

4

Reactant 3

HCID 27343644-(Methanesulfonyl)phenylboronic acidHCID 27735524-Nitrophenylboronic acidHCID 68299353HCID 68299353, compound

Product 1

HCID 57414987HCID 57414987, compound

Procedure

The procedure of Example 27 was repeated except for using 7-bromo-4-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yloxy)-5-methyl-5H-pyrrolo[3,2-d]pyrimidine and 4-nitrophenylboronic acid instead of 7-bromo-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)-5-methyl-5H-pyrrolo[3,2-d]pyrimidine and 4-methanesulfonyl-phenylboronic acid in Step 27-2 to obtain the title compound.

Sources & evidence

ORD record
ord-d51e1afcec084d8e975edcc150996752
Source dataset
uspto-grants-2014_10
Patent number
US08853213B2

Reaction notes

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