Sodium Carbonate → Tert-butyl 4-(7-(4-methanesulfonylphenyl)thieno[3,2-d]pyrimidin-4-yloxy)piperidin-1-carboxylate

참여 물질

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반응 단계

Tert-butyl 4-(7-bromothieno[3,2-d]pyrimidin-4-yloxy)piperidine-1-carboxylate (100 mg), 4-methanesulfonyl-phenylboronic acid (72 mg), Pd(PPh3)4 (17 mg) and 2N Na2CO3 (0.72 mL) were added to 1,4-dioxane (2 mL), and stirred at 100° C. for 12 hours in a hermetically sealed reactor. The reaction mixture was cooled to room temperature, extracted with ethyl acetate and distilled water, and the organic layer thus obtained was washed with water and a saline solution. Subsequently, the washed organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the title compound (25 mg).

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