2-Chloro-5-ethylpyrimidine → HCID 57414347, compound

HRID 532496Notes

Reaction equation

HRID 532496 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:15]3[N:16]=[CH:17][N:18]=[C:19]([NH:20][CH:21]4[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]4)[C:14]=3[S:13][CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].Cl[C:28]1[N:33]=[CH:32][C:31]([CH2:34][CH3:35])=[CH:30][N:29]=1>>[CH2:34]([C:31]1[CH:30]=[N:29][C:28]([N:24]2[CH2:25][CH2:26][CH:21]([NH:20][C:19]3[C:14]4[S:13][CH:12]=[C:11]([C:8]5[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6][CH:7]=5)[C:15]=4[N:16]=[CH:17][N:18]=3)[CH2:22][CH2:23]2)=[N:33][CH:32]=1)[CH3:35]

Participants

3

Reactant 2

HCID 35727632-Chloro-5-ethylpyrimidineHCID 57414213HCID 57414213, compound

Product 1

HCID 57414347HCID 57414347, compound

Procedure

The procedure of intermediate 10 was repeated using 7-(4-methanesulfonyl-phenyl)-N-(piperidin-4-yl)thieno[3,2-d]pyrimidin-4-amine obtained in Example 110 and 2-chloro-5-ethylpyrimidine to obtain the title compound.

Sources & evidence

ORD record
ord-3767d0712ca7473c8076bea84816a4df
Source dataset
uspto-grants-2014_10
Patent number
US08853213B2

Reaction notes

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