Hydrochloric Acid → HCID 68299301, compound

Participants

Reaction Conditions

Reaction Steps

54 mg (0.11 mmol) of tert-butyl 4-(7-(4-methanesulfonyl-phenyl)thieno[3,2-d]pyrimidin-4-ylamino)piperidin-1-carboxylate obtained in Example 109 was dissolved in 2 ml of N,N-dimethylformamide, and 3.4 mg (0.143 mmol) of NaH was added thereto. After 0.5 hr, 10 μl (0.143 mmol) of iodomethane was dropwise added to the mixture at room temperature, heated to 50° C. and stirred for 3 hr. The resulting mixture was neutralized with 1 N aqueous hydrochloride, and extracted twice with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, filtered and distilled under a reduced pressure to obtain 40 mg of the title compound as a pale yellow solid.

Provenance & Evidence