Sodium Carbonate → HCID 68299326, compound

Participants

Reaction Conditions

Reaction Steps

tert-butyl 4-(7-bromo-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl amino)piperidin-1-carboxylate, 73 mg of 4-methanesulfonyl-phenylboronic acid, 17 mg of Pd(PPh3)4 and 0.73 ml of 2N Na2CO3 were added in 3 ml of 1,4-dioxane and stirred in a closed reactor at 100° C. for 12 hr. The resulting mixture was cooled to room temperature, extracted with ethylacetate and distilled water. The organic layer was washed with water and saline solution, dried over anhydrous sodium sulfate and concentrated under a reduced pressure to obtain 15 mg of the title compound.

Provenance & Evidence