HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Trifluoromethylpyridinium hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Chloro-4-(trifluoromethyl)pyridine | HCID 144958 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-Trifluoromethylpyridinium hydrochloride | HCID 19961898 | — |
Reaction Steps
A solution of 2-chloro-4-trifluoromethylpyridine (11.6 g) in glacial acetic acid (70 ml), containing 10% palladium on carbon (2.4 g, 21% (w/w)) was hydrogenated at 40 psi for 4 h. Concentrated hydrochloric acid (20 ml) was added and hydrogenation continued for a further 1 h. The catalyst was filtered off and the filtrate evaporated in vacuo to afford 4-trifluoromethylpyridinium hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05618812 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-c04524e8cfc64b38be348babfd49ccb1 |
| Source note | uspto-grants-1997_04 |