Hydrochloric Acid → HCID 71815240, compound

Participants

Reaction Conditions

Reaction Steps

6-(4-Methoxy-phenyl)-2-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-4-(2-trimethylsilanyl-ethoxymethyl)-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalene (0.33 g, 5.5 mmol) was dissolved in MeOH and treated with concentrated HCl (0.2 mL, 5.5 mmol). The reaction mixture was heated at 100° C. for 4 hr. The solution was cooled to room temperature and the resultant precipitate was filtered, washed with MeOH and concentrated under reduced pressure to provide the corresponding 6-(4-Methoxy-phenyl)-2-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalene (0.26 g, 5.2 mmol) as white solid in 95% yield.

Provenance & Evidence