HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(But-3-yn-2-yl)-1,2,3-trimethoxybenzene → 2,4-Diamino-5-(3-(3,4,5-trimethoxyphenyl)but-1-ynyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(But-3-yn-2-yl)-1,2,3-trimethoxybenzene | HCID 16110325 | — |
| Reactant | 5-Iodopyrimidine-2,4-diamine | HCID 16110335 | — |
| Product | 2,4-Diamino-5-(3-(3,4,5-trimethoxyphenyl)but-1-ynyl)pyrimidine | HCID 16110338 | 90% |
Reaction Steps
2,4-Diamino-5-iodopyrimidine (236 mg) was allowed to react with 5-(But-3-yn-2-yl)-1,2,3-trimethoxybenzene (440 mg) as per the general procedure to afford 2,4-Diamino-5-(3-(3,4,5-trimethoxyphenyl)but-1-ynyl)pyrimidine as a yellow powder (295 mg, 90%): Rf=0.29 (9:1, CHCl3:MeOH); mp=220-222° C.; 1H NMR (DMSO-d6) δ 7.85 (s, 1H), 6.75 (s, 2H), 6.28 (s, 2H), 3.99 (q, J) 6.8 Hz, 1H), 3.78 (s, 6H), 3.63 (s, 3H), 1.50 (d, J) 7.1 Hz, 3H); 13C NMR (DMSO-d6) δ 163.7, 152.8, 139.3, 136.0, 104.2, 104.1, 97.9, 76.2, 60.0, 60.0, 55.9, 55.8, 32.3, 24.3; Anal. (C17H20N4O3) C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853228B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-c745a98144d44c35abc46821fe760570 |
| Source note | uspto-grants-2014_10 |