Propyl isocyanate → HCID 58329393, compound

HRID 533004Notes

Reaction equation

C(O[C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][CH:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=[CH:11][C:10]=2[O:20][CH3:21])=[O:5])C.[CH2:22]([N:25]=[C:26]=[O:27])[CH2:23][CH3:24]>>[CH:17]([N:16]1[C:15]2[C:14]3[CH:13]=[CH:12][CH:11]=[C:10]([O:20][CH3:21])[C:9]=3[N:8]=[CH:7][C:6]=2[C:4](=[O:5])[N:25]([CH2:22][CH2:23][CH3:24])[C:26]1=[O:27])([CH3:18])[CH3:19]

Participants

Reactant 2

HCID 61033Propyl isocyanate

HCID 67248987HCID 67248987, compound

Product 1

HCID 58329393HCID 58329393, compoundYield 35.1%

Procedure

1-Isopropyl-7-methoxy-3-propyl-1H-pyrimido[5,4-c]quinoline-2,4-dione (23 mg) was prepared from 4-isopropylamino-8-methoxy-quinoline-3-carboxylic acid ethyl ester (60 mg, 0.20 mmol) and n-propyl isocyanate (1.0 mmol) following general procedure C. LCMS: m/z 328 [M+1]+.

Sources & evidence

ORD record: ord-4e88d677d2d943a99fb671036225be86
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08853226B2

Reaction notes

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