Methanesulfonyl chloride → 5-Chloro-2-[2-[(methanesulfonyl) oxy]ethyl]-7-[(2,4,6-trimethylphenyl)methoxy]anthra-[1,9-cd]pyrazol-6 (2H) one
Reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[Cl:6][C:7]1[CH:8]=[CH:9][C:10]2[N:11]([CH2:35][CH2:36][OH:37])[N:12]=[C:13]3[C:22]4[C:17](=[C:18]([O:23][CH2:24][C:25]5[C:30]([CH3:31])=[CH:29][C:28]([CH3:32])=[CH:27][C:26]=5[CH3:33])[CH:19]=[CH:20][CH:21]=4)[C:16](=[O:34])[C:15]=1[C:14]=23.ClC1C=CC2N(CCO)N=C3C4C(=CC=CC=4OCC4C(C)=CC(C)=CC=4C)C(=O)C=1C=23>>[Cl:6][C:7]1[CH:8]=[CH:9][C:10]2[N:11]([CH2:35][CH2:36][O:37][S:2]([CH3:1])(=[O:4])=[O:3])[N:12]=[C:13]3[C:22]4[C:17](=[C:18]([O:23][CH2:24][C:25]5[C:30]([CH3:31])=[CH:29][C:28]([CH3:32])=[CH:27][C:26]=5[CH3:33])[CH:19]=[CH:20][CH:21]=4)[C:16](=[O:34])[C:15]=1[C:14]=23Participants
4
Reactant 3
Product 1
Procedure
Starting with methanesulfonyl chloride and the mixture of regioisomers of 5-chloro-2-(2-hydroxyethyl)-7-[(2,4,6-trimethylphenyl)methoxy]anthra-[1,9cd]pyrazol-6-(2H)-one II and 5-chloro-2-(2-hydroxyethyl)-10-[(2,4,6-trimethylphenyl) methoxy]anthra-[1,9-cd]pyrazol-6(2H)-one III, usiong the procedure of example 3, the title compound was prepared.
Sources & evidence
- ORD record
- ord-154881ec22894a5c8b2a4e7da3734674
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05618944
Reaction notes
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