3-Isocyanato-5-methyl-2-(trifluoromethyl)furan → HCID 58329440, compound

HRID 533063Notes

Reaction equation

HRID 533063 reaction equation
C(O[C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][CH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)=[CH:13][CH:12]=[CH:11][C:10]=2[O:22][CH3:23])=[O:5])C.[N:24]([C:27]1[CH:31]=[C:30]([CH3:32])[O:29][C:28]=1[C:33]([F:36])([F:35])[F:34])=[C:25]=[O:26]>>[CH:17]1([N:16]2[C:15]3[C:14]4[CH:13]=[CH:12][CH:11]=[C:10]([O:22][CH3:23])[C:9]=4[N:8]=[CH:7][C:6]=3[C:4](=[O:5])[N:24]([C:27]3[CH:31]=[C:30]([CH3:32])[O:29][C:28]=3[C:33]([F:36])([F:34])[F:35])[C:25]2=[O:26])[CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 27798963-Isocyanato-5-methyl-2-(trifluoromethyl)furanHCID 672497184-Cyclopentylamino-8-methoxy-quinoline-3-carboxylic acid ethyl ester

Product 1

HCID 58329440HCID 58329440, compoundYield 54.4%

Procedure

1-Cyclopentyl-7-methoxy-3-(5-methyl-2-trifluoromethyl-furan-3-yl)-1H-pyrimido[5,4-c]quinoline-2,4-dione (25 mg) was prepared from 4-cyclopentylamino-8-methoxy-quinoline-3-carboxylic acid ethyl ester (0.1 mmol) and 3-isocyanato-5-methyl-2-trifluoromethyl-furan (0.5 mmol) following general procedure C. LCMS: m/z 460 [M+1]+.

Sources & evidence

ORD record
ord-ff64dbd97ca3493ba6106d4945300fab
Source dataset
uspto-grants-2014_10
Patent number
US08853226B2

Reaction notes

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