m-Tolyl isocyanate → HCID 58329378, compound

HRID 533071Notes

Reaction equation

HRID 533071 reaction equation
C(O[C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][CH:17]1[CH2:22][CH2:21][CH:20]([CH3:23])[CH2:19][CH2:18]1)=[CH:13][CH:12]=[CH:11][C:10]=2[O:24][CH3:25])=[O:5])C.[N:26]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([CH3:35])[CH:30]=1)=[C:27]=[O:28]>>[CH3:25][O:24][C:10]1[C:9]2[N:8]=[CH:7][C:6]3[C:4](=[O:5])[N:26]([C:29]4[CH:30]=[C:31]([CH3:35])[CH:32]=[CH:33][CH:34]=4)[C:27](=[O:28])[N:16]([CH:17]4[CH2:22][CH2:21][CH:20]([CH3:23])[CH2:19][CH2:18]4)[C:15]=3[C:14]=2[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 69303m-Tolyl isocyanateHCID 67250000HCID 67250000, compound

Product 1

HCID 58329378HCID 58329378, compoundYield 108.4%

Procedure

7-Methoxy-1-(4-methyl-cyclohexyl)-3-m-tolyl-1H-pyrimido[5,4-c]quinoline-2,4-dione (135 mg) was prepared from 8-methoxy-4-(4-methyl-cyclohexylamino)-quinoline-3-carboxylic acid ethyl ester (0.29 mmol) and 1-isocyanato-3-methyl-benzene (0.44 mmol) following general procedure C. LCMS: m/z 430 [M+1]+.

Sources & evidence

ORD record
ord-cef37ad96ef34837bbd1b909be9bd7d1
Source dataset
uspto-grants-2014_10
Patent number
US08853226B2

Reaction notes

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