5-Isocyanato-1,3-dioxaindane → 4-(3-Benzo[1,3]dioxol-5-yl-7-methoxy-2,4-dioxo-3,4-dihydro-2H-pyrimido[5,4-c]quinolin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][CH:17]1[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH2:18]1)=[CH:13][CH:12]=[CH:11][C:10]=2[O:30][CH3:31])=O)C.[N:32]([C:35]1[CH:43]=[CH:42][C:38]2[O:39][CH2:40][O:41][C:37]=2[CH:36]=1)=[C:33]=[O:34]>>[C:26]([O:25][C:23]([N:20]1[CH2:19][CH2:18][CH:17]([N:16]2[C:15]3[C:14]4[CH:13]=[CH:12][CH:11]=[C:10]([O:30][CH3:31])[C:9]=4[N:8]=[CH:7][C:6]=3[C:4](=[O:3])[N:32]([C:35]3[CH:43]=[CH:42][C:38]4[O:39][CH2:40][O:41][C:37]=4[CH:36]=3)[C:33]2=[O:34])[CH2:22][CH2:21]1)=[O:24])([CH3:29])([CH3:28])[CH3:27]Participants
3
Reactant 2
Product 1
Procedure
4-(3-Benzo[1,3]dioxol-5-yl-7-methoxy-2,4-dioxo-3,4-dihydro-2H-pyrimido[5,4-c]quinolin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (110 mg) was prepared from 4-(1-tert-butoxycarbonyl-piperidin-4-ylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester (0.31 mmol) and 5-isocyanato-benzo[1,3]dioxole (0.465 mmol) following general procedure C. LCMS: m/z 547 [M+1]+.
Sources & evidence
- ORD record
- ord-5fb5fdd4615d46f4b13b25813c71799e
- Source dataset
- uspto-grants-2014_10
- Patent number
- US08853226B2
Reaction notes
Loading…