Methanesulfonyl chloride → HCID 58329426, compound

HRID 533100Notes

Reaction equation

Cl.Cl.[Cl:3][C:4]1[CH:5]=[C:6]([N:10]2[C:25](=[O:26])[C:14]3[CH:15]=[N:16][C:17]4[C:18]([O:23][CH3:24])=[CH:19][CH:20]=[CH:21][C:22]=4[C:13]=3[N:12]([C@@H:27]3[CH2:31][CH2:30][NH:29][CH2:28]3)[C:11]2=[O:32])[CH:7]=[CH:8][CH:9]=1.[CH3:33][S:34](Cl)(=[O:36])=[O:35]>>[Cl:3][C:4]1[CH:5]=[C:6]([N:10]2[C:25](=[O:26])[C:14]3[CH:15]=[N:16][C:17]4[C:18]([O:23][CH3:24])=[CH:19][CH:20]=[CH:21][C:22]=4[C:13]=3[N:12]([C@@H:27]3[CH2:31][CH2:30][N:29]([S:34]([CH3:33])(=[O:36])=[O:35])[CH2:28]3)[C:11]2=[O:32])[CH:7]=[CH:8][CH:9]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 67249613HCID 67249613, compound

Product 1

HCID 58329426HCID 58329426, compound

Procedure

3-(3-Chloro-phenyl)-1-((R)-1-methanesulfonyl-pyrrolidin-3-yl)-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione (29 mg) was prepared according to general procedure H from (R)-3-(3-chloro-phenyl)-7-methoxy-1-pyrrolidin-3-yl-1H-pyrimido[5,4-c]quinoline-2,4-dione.dihydrochloride (42 mg, 0.1 mmol) and methanesulfonyl chloride. LCMS: m/z 501 [M+1]+.

Sources & evidence

ORD record: ord-d466a5961ba84116b9599a46aeb0c39f
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08853226B2

Reaction notes

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