HCID 67973724, compound → HCID 71598742, compound

HRID 533134Notes

Reaction equation

HRID 533134 reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH:9]=[C:8]([C:11]2[CH:12]=[C:13]3[CH2:19][C@@:18]([CH3:26])([CH:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)[O:17][C:14]3=[CH:15][N:16]=2)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[F:27][C:28]([F:39])([F:38])[C:29]1([CH2:32]OS(C)(=O)=O)[CH2:31][CH2:30]1>>[CH3:1][S:2]([N:5]1[CH2:6][CH:7]=[C:8]([C:11]2[CH:12]=[C:13]3[CH2:19][C@:18]([CH3:26])([CH:20]4[CH2:25][CH2:24][N:23]([CH2:32][C:29]5([C:28]([F:39])([F:38])[F:27])[CH2:31][CH2:30]5)[CH2:22][CH2:21]4)[O:17][C:14]3=[CH:15][N:16]=2)[CH2:9][CH2:10]1)(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 67973724HCID 67973724, compoundHCID 86649942(1-(Trifluoromethyl)cyclopropyl)methyl methanesulfonate

Product 1

HCID 71598742HCID 71598742, compound

Procedure

The title compound is prepared from (S)-5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-methyl-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine and methanesulfonic acid (1-trifluoromethyl-cyclopropyl)methyl ester following a procedure analogous to that described for Example 2. LC (method 4): tR=0.64 min; Mass spectrum (ESI+): m/z=500 [M+H]+.

Sources & evidence

ORD record
ord-46afaf6f9a634fd6ac2389ce9301b6b2
Source dataset
uspto-grants-2014_10
Patent number
US08853239B2

Reaction notes

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