反应详情

温度

80 °C

Potassium tert-butoxide (220 g, 1956 mmol) was added to a solution of 2,6-dichloronicotinic acid (180 g, 938 mmol) in MeOH (3000 mL). The mixture was stirred at 80° C. for 48 h. The solvent was evaporated in vacuo. The crude product was dissolved in H2O and treated with HCl (until the pH was 1). The solid was filtered and dried in vacuo to yield 2-chloro-6-methoxy-nicotinic acid as hydrochloride salt (130 g, 70% yield) as a white solid.

1. customThe solvent was evaporated in vacuo
2. dissolutionThe crude product was dissolved in H2O
3. additiontreated with HCl (until the pH was 1)
4. filtrationThe solid was filtered
5. customdried in vacuo