反应详情

温度

100 °C

A mixture of 6-methoxy-2-vinyl-nicotinic acid methyl ester (130 g, 674 mmol) in 7M solution of NH3 in MeOH (500 mL) was added to a sealed vessel. The mixture was stirred at 100° C. for 24 h. The solvent was evaporated in vacuo. The crude product was diluted with MeOH and the mixture was stirred at rt. The solid was filtered and dried in vacuo to yield 2-methoxy-7,8-dihydro-1,6-naphthyridin-5(6H)-one (75 g, 63%) as a solid.

1. additionwas added to a sealed vessel
2. customThe solvent was evaporated in vacuo
3. additionThe crude product was diluted with MeOH
4. stirringthe mixture was stirred at rt
5. filtrationThe solid was filtered
6. customdried in vacuo