HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 533167Generated: October 29, 2026
2-Bromopyridine → HCID 57415343, compound
https://huagongshe.com/reaction/533167
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromopyridine | HCID 7973 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 68008654 | HCID 68008654 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57415343 | HCID 57415343 | — |
Reaction Steps
3-(Benzyloxy)-7,8-dihydro-1,6-naphthyridin-5(6H)-one, example 1.15, (10.0 mg, 0.04 mmol), 2-bromopyridine (8.0 μL, 0.08 mmol), CuI (1.1 mg, 0.006 mmol) and K2CO3 (11.0 mg, 0.08 mmol) were mixed in DMF (0.5 mL), and heated to 150° C. for 2 days. The reaction was partitioned between EtOAc (10 mL) and brine (10 mL). The organics were dried and concentrated and purified by RP-HPLC to afford the compound. LC-MS (M+H)=332.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08853237B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-b6071ff833dc4591903a930296b19e54 |
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| Source note | uspto-grants-2014_10 |
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