Tetrahydrofuran → HCID 58374619, compound

Participants

Reaction Conditions

Reaction Steps

Potassium tert-butoxide (1.3 eq.) was added to an ice-cooled solution of 2-[(triphenyl-λ5-phosphanyl)-methyl]-pyridine (1.1 eq.) in THF (10 mL/mmol). The resulting mixture was stirred for 30 min at 0° C., then at room temperature for another 30 min. A solution of cyclopropanecarboxylic acid [8-(4-formyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide (1 eq.) in THF (10 mL/mmol) was added dropwise to the reaction mixture. The stirring was maintained for 8 hrs. The reaction was then quenched with water and extracted with ethyl actate. The organic phase was dried aver MgSO4, filtered and removed under vacuum. The solid was washed with methanol to afford the title compound in 69% yield.

Provenance & Evidence