HCID 135858790, compound → HCID 135858823, compound

Participants

Reaction Conditions

Reaction Steps

To 7-((benzyl(4-hydroxybutyl)amino)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one (230 mg, 0.70 mmol) in iso-propanol (3 ml) was added 10% Pd—C (50 mg). The mixture was stirred at 50° C. under an atmospheric pressure of H2 overnight. Then the solution was filtered on a pad of Celite and the pad washed with MeOH (10 ml). The filtrate was evaporated to dryness and the residue was chromatographed on silica (DCM-MeOH 8:2+1% cNH3) to give 7-(((4-hydroxybutyl)amino)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one (133 mg, 0.56 mmol, 80% yield) as a white solid. 1H NMR (300 MHz, CD3OD+DCl) 1.64 (2H, m), 1.87 (2H, m), 3.19 (2H, t, J 7.6 Hz), 3.63 (2H, t, J 5.9 Hz), 4.48 (2H, s), 7.87 (1H, s), 9.05 (1H, s); 13C NMR (75 MHz, CD3OD+DCl) 24.7, 30.7, 30.9, 42.1, 62.5, 105.6, 120.2, 133.4, 133.8, 146.8, 153.3.

Provenance & Evidence