Ethanolamine → HCID 135858821, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethanolamine (78 μl, 0.96 mmol), 9-deazahypoxanthine (100 mg, 0.74 mmol) and 37% aq formaldehyde (72 μl, 0.96 mmol) in water (5 ml) was stirred and heated in stoppered flask at 85° C. overnight. The solution was evaporated to dryness and the residue was chromatographed on silica (DCM-MeOH-cNH3 6:3.5:0.5) to give 7-((2-hydroxyethylamino)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one (100 mg, 0.48 mmol, 65% yield) as a pale brown solid. 1H NMR (300 MHz, CD3OD) 2.80 (2H, t, J 5.5 Hz), 3.68 (2H, t, J 5.5 Hz), 3.97 (2H, s), 7.42 (1H, s), 7.88 (1H, s); 13C NMR (75 MHz, MeOD+DCl) 42.0, 50.7, 58.43, 105.2, 120.5, 133.8, 135.0, 147.1, 153.0

Provenance & Evidence