Water → HCID 58158418, compound

Participants

Reaction Steps

7-Bromo-5-(benzyloxymethyl)-4-chloro-5H-pyrrolo[3,2-d]pyrimidine (3.73 g, 10.6 mmol) was dissolved in anhydrous anisole (48 ml) and then diluted with Et2O (145 ml) before being cooled to −78° C. at which point N-butyllithium (1.48M in hexane, 9.2 ml, 13.6 mmol) was added dropwise such that the temperature did not exceed −70° C. Within 2 minutes of the addition, DMF (8.5 ml, 0.123 mol) was introduced quickly (T≦−68° and the mixture stirred whilst warming to −40°, at which point water (20 ml) was added. The mixture was then extracted with EtOAc and the extract washed with brine and then dried and concentrated to an orange solid. Purification of this material was accomplished by chromatography over silica, eluting with 20→40% EtOAc/hexane, to give (a heart fraction of) the title aldehyde (1.83 g, 57.3%) as an off-white solid. 1H NMR (CDCl3) δ 10.35 (s, 1H), 8.89 (s, 1H), 8.14 (s, 1H), 7.35-7.20 (m, 5H), 5.90 (s, 2H), 4.60 (s, 2H).

Provenance & Evidence