Hydrochloric Acid → HCID 136337784, compound

Participants

Reaction Steps

The product from Example 27.6 (0.049 g, 0.15 mmol) was stirred in a 1% hydrogen chloride solution in methanol (10 ml) for 3 h at ambient temperature. The reaction mixture was neutralised with Amberlyst A-21 ion exchange resin. The resin was filtered and the reaction solution concentrated. The residue was chromatographed (methanol [3,5N ammonia solution]-DCM, 1:4) giving a white solid (0.036 g, 83%). 1H NMR revealed this compound to be identical to the enantiomer from Example 26.7. +ESMS Found 299.1180 (M+H)+ C12H19N4O3S requires 299.1178.

Provenance & Evidence