HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl 3-(3-(methylsulfonyloxy)propyl)-1h-indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | ethyl 3-(3-hydroxypropyl)-1H-indole-2-carboxylate | HCID 67316234 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 3-(3-(methylsulfonyloxy)propyl)-1h-indole-2-carboxylate | HCID 87353567 | — |
Reaction Steps
To a mixture of EXAMPLE 3A (0.125 g) and triethylamine (0.21 mL) in acetonitrile (3 mL) at 0-5° C. was added methanesulfonyl chloride (0.0404 mL). After 30 minutes, the mixture was concentrated, and the concentrate was purified by flash chromatography on silica gel with 0-30% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853209B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-22d6a533025f46338385244e57eb3a97 |
| Source note | uspto-grants-2014_10 |